![]() In contrast to a single chain surfactant, a double chain surfactant (gemini) exhibits better interactions with the drug. The stability of the mixed systems is demonstrated by the negative Gibbs free energy of micellization and excess free energy of micellization. The negative values of interaction parameter ( β) and values of activity coefficients less than unity indicate strong synergistic interaction between drug and surfactant. The non-ideal behavior of mixtures was confirmed by the larger values of ideal cmc than the experimental cmc values. The cmc values of mixed amphiphiles were found between the individual amphiphiles due to strong attractive interaction (synergism) between the components after mixing. The critical micelle concentration for single and mixed amphiphiles was estimated. To gain a deep understanding of their mixed association behavior, the outputs were examined using different theoretical models. ![]() ![]() We have estimated micellar, interfacial, and energetic constraints. In this approach, tensiometry and UV-visible techniques are used to determine the effect of cationic gemini and conventional surfactants on tetracaine hydrochloride (TCH), an anesthetic drug. ![]()
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